Endocrine Abstracts

Background: Testosterone acts as a coronary vasodilator, and improves myocardial ischaemia in men with coronary artery disease. The dilatory mechanism of testosterone is independent of the classical androgen receptor and also of the release of endothelial-derived vasodilators. The aim of the present study was to determine whether testosterone has any demonstrable calcium antagonistic action, and if so to determine whether this is via inhibition of voltage-operated calcium chan...

Background: The testicular feminised (Tfm) mouse exhibits an X-linked single base-pair deletion in the gene encoding the androgen receptor. Gene transcription produces a truncated form of the receptor protein, which has a conformational change in the androgen binding site, preventing androgen binding. Affected male animals (XTfmY) are rendered androgen insensitive and 17-alpha hydroxylase deficient, a key enzyme in the steroidogenesis pathway. XTfmY males have reduced circulat...

Various abnormalities of coagulation may occur in patients with thyroid disorders and may range from subclinical laboratory abnormalities to clinically significant disturbances of coagulation. Tissue factor pathway inhibitor (TFPI) is a newly determined potent inhibitor of tissue factor dependent coagulation system. TFPI changes in various thyroid disorders has not been evaluated yet. In this study we have evaluated total TFPI (tTFPI), free TFPI (fTFPI), tissue plasminogen act...

IntroductionEven in healthy men, androgen levels start decreasing from early adulthood and these decreases are more pronounced in men with an increasing body mass index (BMI). It is, however, unclear to what extent changes in other indices of body composition and metabolic health are associated with changes in sex steroid exposure in healthy men over time.ObjectiveInvestigating longitudinal changes in body co...

Background and Objectives: Non-alcoholic fatty liver disease (NAFLD) is the presence of hepatic steatosis in the absence of other causes for secondary hepatic fat accumulation. The incidence and the prevalence of the NAFLD has risen exponentially in the recent past especially in the patients with diabetes. We have studied the prevalence of NAFLD in patients with diabetes attending the diabetes clinic based on the biochemical and ultrasonic criteria, the risk factors for diseas...

Introduction: Neuroendocrine tumours (NETs) of unknown primary site are relatively uncommon, representing about 10% of all NETs. Of these, particularly the well-differentiated NETs often present initially with liver metastases, and most of these represent gastroenteropancreatic NETs. The presence of carcinoid syndrome is also common.Case presentation: We describe the case of a 40 years-old patient presented in 2013 with flushing, diarrhea, and back pain....

Introduction: Isolated IgA deficiency (SIgAD) is the most common form of primary immunodeficiency. Patients with SIgAD have an increased risk of both systemic and organ-specific autoimmune diseases. Autoimmune thyroid diseases (AITD) and type 1 diabetes mellitus (T1DM) are the most common autoimmune endocrine disorders. They occur frequently together, and this combination is nominated as autoimmune polyglandular syndrome type 3 (APS 3). Primary hyperparathyroidism (PHPT) is th...

Polycystic ovary syndrome (PCOS) is a characterized by hyperandrogenism and irregular menses and is associated with insulin resistance, type 2 diabetes and obesity. While there is a strong genetic component to PCOS, candidate gene analyses and genome wide association studies (GWAS) have identified only a handful of replicated PCOS susceptibility loci. Therefore, we employed a candidate pathway approach to identify additional PCOS susceptibility loci. This approach is more comp...

Aims: To compare glycaemic control and weight gain in children with type 1 diabetes changing from twice daily premixed insulin to multiple daily injections (MDI) with either insulin glargine or insulin detemir.Methods: A retrospective study of 41 consecutive children and adolescents with type 1 diabetes, changed to MDI between January 2005 and April 2007, with outcome measures of HbA1C change and body mass index SDS (BMI-SDS) change after 12 months of MD...

Introduction: LH and hCG act on the same receptor (LHCGR), but it is not known whether they elicit the same cellular and molecular response. This study aims at comparing the activation of cell-signalling pathways and gene expression in response to LH and hCG.Design: We evaluated the activation of cAMP, ERK and AKT-pathways and progesterone production by ELISA and Western blotting in human primary granulosa cells (hGLC) stimulated for up to 36 hours with ...